A cell is said to be homozygous for a particular gene when identical alleles of the gene are present on both homologous chromosomes.
The homozygous mouse model is a commonly utilized lab animal that has been edited genetically to have two identical copies of a specific gene. This model is extensively employed in scientific investigations to examine different genetic disorders and diseases.
With traditional technology, it takes at least 2-3 generations of breeding and screening to get the homozygous mice from funder mice, which costs a total of 10-12 months with low success rates.
